Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity.

TitleEffects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity.
Publication TypeJournal Article
Year of Publication2022
AuthorsHunagund, S, Golan, Y, Asiodu, IV, Prahl, M, Gaw, SL
JournalFront Immunol
Volume13
Pagination910383
Date Published2022
ISSN1664-3224
KeywordsCOVID-19, COVID-19 Vaccines, Female, Health Equity, Humans, Immunoglobulin A, Secretory, Immunoglobulin G, Infant, Influenza Vaccines, Influenza, Human, Milk, Human, Pregnancy, SARS-CoV-2, Vaccination, Whooping Cough
Abstract

Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed.
DOI10.3389/fimmu.2022.910383
Alternate JournalFront Immunol
PubMed ID35903100
PubMed Central IDPMC9314549
Grant ListK08 AI141728 / AI / NIAID NIH HHS / United States
K12 HD052163 / HD / NICHD NIH HHS / United States
K23 AI127886 / AI / NIAID NIH HHS / United States