| Title | Education differentially contributes to cognitive reserve across racial/ethnic groups. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Avila, JF, Rentería, MArce, Jones, RN, Vonk, JMJ, Turney, I, Sol, K, Seblova, D, Arias, F, Hill-Jarrett, T, Levy, S-A, Meyer, O, Racine, AM, Tom, SE, Melrose, RJ, Deters, K, Medina, LD, Carrión, CI, Díaz-Santos, M, Byrd, DAR, Chesebro, A, Colon, J, Igwe, KC, Maas, B, Brickman, AM, Schupf, N, Mayeux, R, Manly, JJ |
| Journal | Alzheimers Dement |
| Volume | 17 |
| Issue | 1 |
| Pagination | 70-80 |
| Date Published | 2021 Jan |
| ISSN | 1552-5279 |
| Keywords | Aged, Aged, 80 and over, Aging, Black or African American, Black People, Brain, Cognitive Aging, Cognitive Reserve, Educational Status, Ethnicity, Female, Hispanic or Latino, Humans, Language, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Racial Groups, White Matter, White People |
| Abstract | INTRODUCTION: We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. METHODS: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. RESULTS: Higher educational attainment attenuated the negative impact of WMH burden on memory (β = -0.03; 99% CI: -0.071, -0.002) and language decline (β = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. DISCUSSION: Educational attainment does not contribute to CR similarly across racial/ethnic groups. |
| DOI | 10.1002/alz.12176 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 32827354 |
| PubMed Central ID | PMC8376080 |
| Grant List | UL1 TR001863 / TR / NCATS NIH HHS / United States RF1 AG066107 / AG / NIA NIH HHS / United States P01 AG007232 / AG / NIA NIH HHS / United States RF1 AG054023 / AG / NIA NIH HHS / United States R01 AG037212 / AG / NIA NIH HHS / United States UL1 TR001873 / TR / NCATS NIH HHS / United States R01 AG072474 / AG / NIA NIH HHS / United States R13 AG030995 / AG / NIA NIH HHS / United States |
