| Title | Decreased enrollment in breast cancer trials by histologic subtype: does invasive lobular carcinoma resist RECIST? |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Abel, MKathryn, Melisko, ME, Rugo, HS, A Chien, J, Diaz, I, Levine, JK, Griffin, A, McGuire, J, Esserman, LJ, Borno, HT, Mukhtar, RA |
| Journal | NPJ Breast Cancer |
| Volume | 7 |
| Issue | 1 |
| Pagination | 139 |
| Date Published | 2021 Oct 25 |
| ISSN | 2374-4677 |
| Abstract | Enrollment in metastatic breast cancer trials usually requires measurable lesions, but patients with invasive lobular carcinoma (ILC) tend to form diffuse disease. We found that the proportion of patients with metastatic ILC enrolled in clinical trials at our institution was significantly lower than that of patients with invasive ductal carcinoma (IDC). Possible links between requiring measurable disease and decreased enrollment of ILC patients require further study to ensure equitable trial access. |
| DOI | 10.1038/s41523-021-00348-z |
| Alternate Journal | NPJ Breast Cancer |
| PubMed ID | 34697300 |
| PubMed Central ID | PMC8547221 |
| Grant List | K08 CA256047 / CA / NCI NIH HHS / United States |